Prevalence of Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo-BetaLactamases (MBLs) Among Healthy and Hospitalized Children in Abraka and Eku Communities, Delta State, Nigeria

This study was conducted to detect the prevalence of Metallo-Beta-Lactamases (MBLs) and Extended Spectrum Beta-Lactamases (ESBLs) in bacterial isolates from clinical community settings two communities Delta State, Nigeria. Eighty four obtained blood, urine, wound stool patients subjects were analyzed identified by standard microbiological methods. Carbapenemase detection carried out using modified Hodge test. EDTA-disc synergy test used todetect MBLs production 26.2% isolates. ESBLs determined double disc (DDST) detected 36.7% Escherichia coli, 37.5% Pseudomonas aeruginosa 75% Klebsiella pneumoniae. Co-production MBL ESBL observed 31.8% The 2 major troubling findings. first is co-production both hospitalized healthy children. Second, antibiotic resistantbacteria may be able persist free high selective pressure pervading settings. There therefore need for increased surveillance.
 Keywords: Antibiotic resistance, Multidrug Healthy children, Beta-lactamases, Plasmids